Systemic immune-inflammation index is associated with coronary heart disease: a cross-sectional study of NHANES 2009–2018

Background Inflammation has been linked to the development of coronary heart disease (CHD). The systemic immune inflammation index (SII) is a useful biomarker inflammation. Our study aimed explore correlation between SII and CHD. Methods We conducted multivariate logistic regression analysis, smoothing curve fitting, segmented model comparison on 15,905 participants with CHD prevalence 3.31% mean age 46.97 years. Results Adjusting for gender, age, race, we found negative association [odds ratio (OR) 0.66; 95% confidence interval (CI) 0.48, 0.90]. There was an inverse trend where increasing associated decreasing odds ( p = 0.0017). After further adjustment, strengthened, similar 0.0639). Smoothing fitting demonstrated gender-specific Conclusions findings suggest that higher values may be incidence CHD, which varies by gender. cost-effective convenient method detect Further studies are needed confirm causality these in larger prospective cohort.